Top News from Leading Digital Manufacturing Solution Providers
January 11, 2013
Molecular Machine Could Yield More Efficient Manufacturing
MANCHESTER, Jan. 11 – An industrial revolution on a minute scale is taking place in laboratories at The University of Manchester with the development of a highly complex machine that mimics how molecules are made in nature.
The artificial molecular machine developed by Professor David Leigh FRS and his team in the School of Chemistry is the most advanced molecular machine of its type in the world. Its development has been published in the journal Science.
Professor Leigh explains: "The development of this machine which uses molecules to make molecules in a synthetic process is similar to the robotic assembly line in car plants. Such machines could ultimately lead to the process of making molecules becoming much more efficient and cost effective. This will benefit all sorts of manufacturing areas as many manmade products begin at a molecular level. For example, we're currently modifying our machine to make drugs such as penicillin."
The machine is just a few nanometres long (a few millionths of a millimetre) and can only be seen using special instruments. Its creation was inspired by natural complex molecular factories where information from DNA is used to programme the linking of molecular building blocks in the correct order. The most extraordinary of these factories is the ribosome, a massive molecular machine found in all living cells.
Professor Leigh's machine is based on the ribosome. It features a functionalized nanometre-sized ring that moves along a molecular track, picking up building blocks located on the path and connecting them together in a specific order to synthesize the desired new molecule.
First the ring is threaded onto a molecular strand using copper ions to direct the assembly process. Then a "reactive arm" is attached to the rest of the machine and it starts to operate. The ring moves up and down the strand until its path is blocked by a bulky group. The reactive arm then detaches the obstruction from the track and passes it to another site on the machine, regenerating the active site on the arm. The ring is then free to move further along the strand until its path is obstructed by the next building block. This, in turn, is removed and passed to the elongation site on the ring, thus building up a new molecular structure on the ring. Once all the building blocks are removed from the track, the ring de-threads and the synthesis is over.
Professor Leigh says the current prototype is still far from being as efficient as the ribosome: "The ribosome can put together 20 building blocks a second until up to 150 are linked. So far we have only used our machine to link together 4 blocks and it takes 12 hours to connect each block. But you can massively parallel the assembly process: We are already using a million million million (1018) of these machines working in parallel in the laboratory to build molecules."
Professor Leigh continues: "The next step is to start using the machine to make sophisticated molecules with more building blocks. The potential is for it to be able to make molecules that have never been seen before. They're not made in nature and can't be made synthetically because of the processes currently used. This is a very exciting possibility for the future."
At this year’s Supercomputing conference, Ohio made its mark with a $6.4 million public-private initiative designed to bring high performance computing (HPC) to manufacturers of all sizes—particularly to those small-to-medium-sized companies for which the technologies are cost-prohibitive. Read more...
A consortium of 45 partners have assembled in Europe with the hope of fortifying the international manufacturing marketplace through modeling and simulation tools. After an initial phase of closed testing led by the Edinburgh Parallel Computing Centre (EPCC), the new HPC cloud project is opening its doors. Read more...
It’s no secret that going virtual to engineer and test new cars, planes or even consumer products saves money, particularly if it means going through multiple versions of a single design. But at October’s Matlab Expo, software engineers and scientists came together to paint a new image of software as something beyond a mere sandbox: a playground. Read more...
Dec 05, 2013 |
Back in July, Curiosity, NASA’s Mars rover, began a 5.3 mile journey to Mount Sharp, a 3.4 mile-high mountain in the Gale Crater. However, in late October, the rover completed a two-day drive all on its own thanks to Carnegie Mellon University’s Robotics Institute and their autonomous navigation software. Read more...
Dec 04, 2013 |
On September 2, 2013, the EU project titled “LIAA” was set in motion. With the project, scientists will help to develop robotic systems and applications that will be used for assembly in manufacturing, and in doing so help humans and robots to better work together. Read more...
Nov 26, 2013 |
Siemens Industry Software India (SISW) has signed an agreement with the Government of Gujarat’s Ministry of Industries and Mines to launch five Centers of Excellence (COEs) in the state. These centers will specifically be aimed at skill development in higher education. Read more...
Nov 14, 2013 |
At a time when finding a job is first on the minds of many, companies continue to outsource positions overseas. However, at the National Retail Federation’s annual convention back in January 2013... Read more...
07/30/2013 | IBM | This white paper examines various means of adapting technical computing tools to accelerate product and services innovation across a range of commercial industries such as manufacturing, financial services, energy, healthcare, entertainment and retail. No longer is technically advanced computing limited to the confines of big government labs and academic centers. Today it is available to a wide range of organizations seeking a competitive edge.
06/25/2013 | Intel | The UberCloud HPC Experiment has achieved the volunteer participation of 500 organizations and individuals from 48 countries with the aim of exploring the end-to-end process employed by digital manufacturing engineers to access and use remote computing resources in HPC centers and in the cloud. This Compendium of 25 case studies is an invaluable resource for engineers, managers and executives who believe in the strategic importance of applying advanced technologies to help drive their organization’s productivity to perceptible new levels.